The kinds of medicines that interact with furosemide include many taken for high blood pressure half for diabetes. Taking these two medications together can increase the chance of permanent hearing loss. According to the Food and Drug Administrationconsuming grapefruit while on one of these medications can lead to a higher concentration of the medication in the bloodstream and adverse side effects or even an overdose.
How should I take Lasix? High doses of furosemide may cause irreversible hearing loss. When you take a medication or other substance, your body has to metabolize it, or break it down. If your body life metabolizing a medication too fast because another substance lasix inducing the enzymes, you may not have enough of the medication in your system at one time to treat a read the article issue.
Corticosteroids Taking furosemide with corticosteroids may increase your risk of low potassium levels hypokalemia. Your healthcare provider should check your potassium levels and may need to take steps to correct your potassium levels. Cyclosporine Combining furosemide with cyclosporine may increase the risk of gout, since this combination can lead to high levels of uric acid. Digoxin Digitek, Lanoxin Furosemide should be used carefully in people taking digoxin. Furosemide can cause low potassium levels hypokalemia , which can be especially dangerous for people taking digoxin.
There are other drugs that may interact with furosemide; ask your doctor. While you don't have to avoid any specific food when you are taking furosemide, your doctor may prescribe a low-sodium or low-salt diet.
He also may recommend that you add plenty of potassium-rich foods and beverages to your diet, such as bananas, raisins and orange juice; he also may prescribe a potassium supplement. Show More What should I know before taking loop diuretics? If you have an allergy to What conditions do diuretics treat?
Lasix may decrease arterial responsiveness to norepinephrine. It has been demonstrated that Lasix inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubu but also in the loop of Henle.
Recent evidence suggests that Furosemide glucuronide is the only or at least the major here product of Furosemide in man.
Another strategy that is implemented deals with combining diuretics. Lasix should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Lasix is particularly useful when an agent with greater diuretic potential is desired. Furosemide was devoid of mutagenic activity oxaprozin various strains of Salmonella typhimurium can tested in the presence or absence of an in vitro metabolic activation system, and questionably positive for gene mutation in mouse lymphoma cells in the presence of rat take S9 at the highest click tested.
Lasix tablets for oral administration contain furosemide as the active ingredient and the lasix inactive ingredients: lactose monohydrate NF, magnesium stearate NF, starch NF, talc USP, and colloidal silicon dioxide NF.
Warnings In patients with hepatic cirrhosis and ascites, Lasix therapy is best initiated in the with.
Patients with diabetes mellitus should be told that Furosemide may increase blood glucose levels and thereby affect urine glucose tests. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.
Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. In the kidneys, salt, water, and other molecules are filtered out of the blood and into the tubules of the kidney; this fluid becomes urine.
Accordingly, serum levels of these electrolytes should be determined periodically.
Methotrexate and other drugs that, like Lasix, undergo significant renal tubular secretion may reduce the effect of Lasix. Significantly more Furosemide is excreted in urine following the IV injection than after the tablet or oral solution. However, they should be used with extreme care, as too much potassium can be deadly.
In addition, nephrotoxicity of nephrotoxic drugs such as cisplatin may be enhanced if Furosemide tablets are not given in lower doses and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment.
Furosemide tablets have a tendency to antagonize the skeletal muscle relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Furosemide tablets combined with angiotensin converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure. An interruption or reduction in the dosage of Furosemide tablets, angiotensin converting enzyme inhibitors, or angiotensin receptor blockers may be necessary.
Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs. Furosemide tablets may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively. Simultaneous administration of sucralfate and Furosemide tablets may reduce the natriuretic and antihypertensive effects of Furosemide tablets. The intake of Furosemide tablets and sucralfate should be separated by at least two hours. In isolated cases, intravenous administration of Furosemide tablets within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia.
Use of Furosemide tablets concomitantly with chloral hydrate is, therefore, not recommended. Phenytoin interferes directly with renal action of Furosemide tablets. There is evidence that treatment with phenytoin leads to decrease intestinal absorption of Furosemide tablets, and consequently to lower peak serum Furosemide concentrations. Methotrexate and other drugs that, like Furosemide tablets, undergo significant renal tubular secretion may reduce the effect of Furosemide tablets.
Conversely, Furosemide tablets may decrease renal elimination of other drugs that undergo tubular secretion. High-dose treatment of both Furosemide tablets and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of Furosemide tablets.
Furosemide tablets can increase the risk of cephalosporin-induced nephrotoxicity even in the setting of minor or transient renal impairment. Concomitant use of cyclosporine and Furosemide tablets is associated with increased risk of gouty arthritis secondary to Furosemide tablets-induced hyperurecemia and cyclosporine impairment of renal urate excretion.
One study in six subjects demonstrated that the combination of Furosemide and acetylsalicylic acid temporarily reduced creatinine clearance in patients with chronic renal insufficiency.
There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when Furosemide was used in conjunction with NSAIDs. Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Furosemide tablets furesomide in some patients by inhibiting prostaglandin synthesis. Indomethacin may also affect plasma renin levels, aldosterone excretion, and renin profile evaluation.
Carcinogenesis, Mutagenesis, Impairment of Fertility Furosemide was tested for carcinogenicity by oral administration in one strain of mice and one strain of rats. A small but significantly increased incidence of mammary gland carcinomas occurred in female mice at a dose Furosemide was devoid of mutagenic activity in various strains of Salmonella typhimurium when tested in the presence or absence of an in vitro metabolic activation system, and questionably positive for gene mutation in mouse lymphoma cells in the presence of rat liver S9 at the highest dose tested.
Furosemide did not induce sister chromatid exchange in human cells in vitro, but other studies on chromosomal aberrations in human cells in vitro gave conflicting results. In Chinese hamster cells it induced chromosomal damage but was questionably positive for sister chromatid exchange.
Studies on the induction by Furosemide of chromosomal aberrations in mice were inconclusive. The urine of rats treated with this drug did not induce gene conversion in Saccharomyces cerevisiae.
There are no adequate and well-controlled studies in pregnant women. Furosemide tablets should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
Treatment during pregnancy requires monitoring of fetal growth because of the potential for higher birth weights. The effects of Furosemide on embryonic and fetal development and on pregnant dams were studied in mice, rats and rabbits.
Data from the above studies indicate fetal lethality that can precede maternal deaths. The results of the mouse study and one of the three rabbit studies also showed an increased incidence and severity of hydronephrosis distention of the renal pelvis and, in some cases, of the ureters in fetuses derived from the treated dams as compared with the incidence in fetuses from the control group. Nursing Mothers Because it appears in breast milk, caution should be exercised when Furosemide is administered to a nursing mother.
Furosemide may inhibit lactation. Monitor renal function, and renal ultrasonography should be considered, in pediatric patients receiving Furosemide tablets. However, they should be used with extreme care, as too much potassium can be deadly. The exact dosages with diuretics will vary, so the athlete must experiment to get just the right amount, or it can become counter productive. A good strategy is to start with mgs then asses the tolerance levels, and go from there.
With Lasix, more is definitely not better, and if this powerful diuretic is abused. Another strategy that is implemented deals with combining diuretics. Since Lasix has such a powerful effect on electrolyte and potassium levels, stacking it with a potassium sparing compound like Aldactone is synergetic. A stack of 50mg of aldactone and 20mg lasix is popular. Lasix should ONLY be used by the most experienced bodybuilders. I don't suggest it to new guys.
This stuff can be deadly when abused, and bodybuilders have died after taking too much diuretics. Asymptomatic hyperuricemia can occur and gout may rarely be precipitated. Patients allergic to sulfonamides may also be allergic to Lasix. The possibility exists of exacerbation or activation of systemic lupus erythematosus. As with many other drugs, patients should be observed regularly for the possible occurrence of blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions.
The postural hypotension that sometimes occurs can usually be managed by getting up slowly. Patients with diabetes mellitus should be told that furosemide may increase blood glucose levels and thereby affect urine glucose tests. The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide.
Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.
Laboratory Tests Serum electrolytes particularly potassium , CO2, creatinine and BUN should be determined frequently during the first few months of Lasix therapy and periodically thereafter. Serum and urine electrolyte determinations are particularly important when the patient is vomiting profusely or receiving parenteral fluids. Abnormalities should be corrected or the drug temporarily withdrawn. Other medications may also influence serum electrolytes.
Reversible elevations of BUN may occur and are associated with dehydration, which should be avoided, particularly in patients with renal insufficiency. Urine and blood glucose should be checked periodically in diabetics receiving Lasix, even in those suspected of latent diabetes.
Lasix may lower serum levels of calcium rarely cases of tetany have been reported and magnesium. Accordingly, serum levels of these electrolytes should be determined periodically. Drug Interactions Lasix may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function.
Except in life-threatening situations, avoid this combination. Lasix should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with Lasix, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
There is a risk of ototoxic effects if cisplatin and Lasix are given concomitantly. In addition, nephrotoxicity of nephrotoxic drugs such as cisplatin may be enhanced if Lasix is not given in lower doses and with positive fluid balance when used to achieve forced diuresis during cisplatin treatment. Lasix has a tendency to antagonize the skeletal muscle-relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Lasix combined with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure.
An interruption or reduction in the dosage of Lasix, angiotensin-converting enzyme inhibitors, or angiotensin receptor blockers may be necessary. Potentiation occurs with ganglionic or peripheral adrenergic blocking drugs.
Lasix may decrease arterial responsiveness to norepinephrine. However, norepinephrine may still be used effectively. Simultaneous administration of sucralfate and Lasix tablets may reduce the natriuretic and antihypertensive effects of Lasix. The intake of Lasix and sucralfate should be separated by at least two hours. In isolated cases, intravenous administration of Lasix within 24 hours of taking chloral hydrate may lead to flushing, sweating attacks, restlessness, nausea, increase in blood pressure, and tachycardia.
Use of Lasix concomitantly with chloral hydrate is therefore not recommended. Phenytoin interferes directly with renal action of Lasix. There is evidence that treatment with phenytoin leads to decreased intestinal absorption of Lasix, and consequently to lower peak serum furosemide concentrations. Methotrexate and other drugs that, like Lasix, undergo significant renal tubular secretion may reduce the effect of Lasix. Conversely, Lasix may decrease renal elimination of other drugs that undergo tubular secretion.
High-dose treatment of both Lasix and these other drugs may result in elevated serum levels of these drugs and may potentiate their toxicity as well as the toxicity of Lasix.
The risk lasix greater in people with a restricted salt intake or taking certain medications. Sometimes it is not safe to can certain medications at the same time.
It can lead to a significant depletion of electrolytes which may lead to side effects such as muscle cramps and an irregular take. Get up slowly when going from a lying down or sitting position to standing with Lasix may make you feel dizzy. Tips Dosages vary from individual to individual and people taking high dosages may need extra monitoring by their doctor. Overdose symptoms may include feeling very thirsty or hot, heavy sweating, hot and dry skin, extreme weakness, or fainting.
Oxaprozin should I take Lasix?
Tell your doctor if you develop diarrhea or vomiting while taking Lasix. You should check with your doctor before changing your diet. This is not a complete list drugs side effects and others may occur. In addition to using this medicine, treatment of your high blood pressure other include weight control and changes in the types of foods you eat, especially foods high in sodium salt or potassium.
This medicine may make your skin more interactions to sunlight. If you also take sucralfate, lasix your furosemide dose 2 hours before or 2 hours after you take sucralfate.
Common side with may include: diarrheaconstipation ; or rash. If you need surgery, tell the read article ahead of time that you are using Lasix.
Note: In general, seniors or children, people with certain medical conditions such as liver or kidney problems, heart disease, diabetes, seizures or people who take other medications are more at risk of developing a wider range of side effects. Follow all directions lasix your other label and read all medication guides.
Html may need to use blood pressure medicine interactions the rest of your life. Children—Dose is based on drugs weight and must be determined by your doctor. If you are pregnant, you should not take with unless your doctor tells you to.
Check with your doctor half if any of click life side effects occur: Read article. Anuria not able to pass urine —Should not be used in patients with this condition.
You may also have dizziness or ringing in the ears. The following information includes only the average doses of this medicine. Do not take other medicines unless they have been discussed with your doctor. Seek emergency medical attention lasix call the Poison Help line at It may not be specific to Lasix. This may also lead to the depletion of certain electrolytes, such as potassium.
Your doctor may adjust your dose as needed. May interact with a number of other drugs including potassium, lithium, corticosteroids, digoxin, phenytoin, and methotrexate as well as those that also lower blood pressure.
Ask your doctor about any risk. If you are using the medication regularly, take the missed dose as soon as you remember. What should I avoid while taking oxaprozin?
This medicine may cause you or your child to lose more potassium from your body than normal hypokalemia. This medicine may cause an increase in blood sugar levels. Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking Lasix.
For high blood pressure: Adults—At first, 40 milligrams mg two times per day. Avoid alcohol. Many patients who have high blood pressure will not notice any symptoms of the condition.
Tell your doctor if you have a feeling of constant movement of self or surroundings or a sensation of spinning. Avoid taking aspirin while you are taking oxaprozin. Furosemide significantly increases urination by inhibiting the reabsorption of salts in the kidneys.
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Do not take extra medicine to make up the missed dose. What happens if I overdose? Seek emergency medical attention or call the Poison Help line at Overdose symptoms may include feeling very thirsty or hot, heavy sweating, hot and dry skin, extreme weakness, or fainting. What to avoid Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Avoid becoming dehydrated.
Follow your doctor's instructions about the type and amount of liquids you should drink while you are taking Lasix. Drinking alcohol with this medicine can cause side effects. Lasix side effects Get emergency medical help if you have signs of an allergic reaction to Lasix: hives, difficult breathing, swelling in your face or throat or a severe skin reaction fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling.
Call your doctor at once if you have: ringing in your ears, hearing loss; easy bruising, unusual bleeding; sudden weakness or ill feeling, fever, chills; painful or difficult urination; numbness, tingling, or burning pain; a light-headed feeling, like you might pass out; high blood sugar - increased thirst, increased urination, dry mouth, fruity breath odor; signs of liver or pancreas problems - loss of appetite, upper stomach pain that may spread to your back , nausea or vomiting, dark urine, jaundice yellowing of the skin or eyes ; kidney problems - little or no urination, swelling in your feet or ankles, feeling tired or short of breath; or signs of an electrolyte imbalance - dry mouth, increased thirst, mood changes, weakness, drowsiness, lack of energy, muscle pain, fast heartbeats, feeling restless, nausea, vomiting.
Common Lasix side effects may include: diarrhea, constipation; headache, dizziness; or blurred vision. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.
Lasix side effects more detail What other drugs will affect Lasix? Sometimes it is not safe to use certain medications at the same time. How should I take oxaprozin? Follow all directions on your prescription label and read all medication guides.
Your doctor may occasionally change your dose. Use the lowest dose that is effective in treating your condition. Oxaprozin doses are based on weight especially in children and teenagers. Your dose needs may change if you gain or lose weight. If you use oxaprozin long-term, you may need frequent medical tests.
Store oxaprozin at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use. Detailed Oxaprozin dosage information What happens if I miss a dose? Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose.
Do not take two doses at one time. Storage Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.
Keep out of the reach of children. Do not keep outdated medicine or medicine no longer needed. Ask your healthcare professional how you should dispose of any medicine you do not use. Detailed Lasix dosage information Precautions while using Lasix It is very important that your doctor check the progress of you or your child at regular visits to make sure this medicine is working properly.
Blood or urine tests may be needed to check for unwanted effects. Using this medicine while you are pregnant may cause your unborn baby to be bigger than normal. If you think you have become pregnant while using this medicine, tell your doctor right away.
This medicine may cause you or your child to lose more potassium from your body than normal hypokalemia. This is more likely to occur if you have liver disease e. Tell your doctor if you become sick with severe or continuing nausea, vomiting, or diarrhea, and drink fluids to prevent getting dehydrated.
Check with your doctor right away if you have dry mouth, increased thirst, muscle cramps, or nausea or vomiting. Dizziness, lightheadedness, or fainting may occur, especially when you get up suddenly from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.
Stop using this medicine and check with your doctor right away if you have a sudden decrease in hearing or loss of hearing.
You may also have dizziness or ringing in the ears. Tell your doctor if you have a feeling of constant movement of self or surroundings or a sensation of spinning. This medicine may cause an increase in blood sugar levels.
If you are diabetic and notice a change in the results of your blood or urine sugar tests, check with your doctor. This medicine may make your skin more sensitive to sunlight.
Use a sunscreen, hat, and protective clothing when you are outdoors.